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Updated: May 1, 2026
07:34
Large Scale Non-targeted Metabolomic Profiling of Serum by Ultra Performance Liquid Chromatography-Mass Spectrometry UPLC-MS
Published on: March 14, 2013
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Clinical metabolomics: current state and prospects in Russia
P G Lokhov1, E E Balashova1, O P Trifonova1
1Institute of Biomedical Chemistry, Moscow, Russia.
Biomeditsinskaia Khimiia
|September 26, 2024
Summary
Clinical blood metabograms (CBM) offer a comprehensive view of a patient's metabolic state, advancing diagnostics beyond traditional methods. This metabolomic approach aids in disease monitoring and treatment evaluation.
Area of Science:
- Biomedical Science
- Analytical Chemistry
- Clinical Diagnostics
Background:
- Current clinical diagnostics measure limited biomarkers.
- Metabolomic technologies analyze thousands of molecules in biological samples.
- Challenges exist in integrating metabolomics into clinical practice.
Purpose of the Study:
- To review the development and implementation of the clinical blood metabogram (CBM).
- To highlight the potential of CBM in clinical laboratory diagnostics.
- To discuss the achievements of the Institute of Biomedical Chemistry (IBMC) in clinical metabolomics.
Main Methods:
- Utilizing advanced analytical technologies for comprehensive molecular profiling.
- Developing and applying the clinical blood metabogram (CBM) for blood sample analysis.
- Analyzing CBM patterns (signatures) for disease diagnosis and monitoring.
Main Results:
- The development of the clinical blood metabogram (CBM) by IBMC.
- CBM provides an overview of the body's state with individual metabolic details.
- Scientific studies confirm CBM's effectiveness in monitoring body status and aiding disease management.
Conclusions:
- The clinical blood metabogram represents a significant advancement in clinical metabolomics.
- CBM facilitates improved diagnosis and monitoring of various diseases.
- The development of CBM is crucial for the current state and future of clinical metabolomics in Russia.
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