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Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

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Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
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Diabetes Mellitus: Overview and Type I Subtype01:22

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Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
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Pathophysiology of Diabetes01:20

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Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
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What is the Immune System?01:38

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Diabetes Mellitus: Type 2 and Gestational01:22

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Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
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Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

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Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
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Related Experiment Video

Updated: Mar 24, 2026

Accelerated Type 1 Diabetes Induction in Mice by Adoptive Transfer of Diabetogenic CD4+ T Cells
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[Intercurrent and autoimmune processes in type 1 diabetes mellitus].

O S Derevyanko1, T V Nikonova1, O M Smirnova1

  • 1Endocrinology Research Centre, Ministry of Health of Russia, Moscow, Russia.

Terapevticheskii Arkhiv
|March 16, 2016
PubMed
Summary

Patients with type 1 diabetes mellitus (DM1) often have markers for other autoimmune diseases, even without symptoms. This suggests a higher risk of co-occurring conditions in individuals with DM1.

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Electrochemiluminescence Assays for Human Islet Autoantibodies
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Area of Science:

  • Endocrinology
  • Immunology
  • Hepatology

Context:

  • Type 1 diabetes mellitus (DM1) is an autoimmune condition.
  • Co-occurring autoimmune diseases are common in DM1 patients.
  • Autoantibodies are key indicators of autoimmune diseases.

Purpose:

  • To determine the prevalence of autoantibodies linked to connective tissue and liver autoimmune diseases in DM1 patients.
  • To analyze the clinical characteristics of DM1 patients who test positive for these autoantibodies.

Summary:

  • A study of 84 patients with DM1 revealed a high prevalence of autoantibodies associated with connective tissue and liver autoimmune diseases.
  • These autoantibodies were detected even in DM1 patients lacking clinical symptoms or instrumental signs of these conditions.
  • The findings indicate a significant overlap between DM1 and other autoimmune disorders.

Impact:

  • Suggests an increased risk of concomitant autoimmune diseases in individuals with type 1 diabetes mellitus.
  • Highlights the potential for asymptomatic autoimmune conditions in DM1 patients.
  • Emphasizes the importance of screening for other autoimmune diseases in DM1 management.