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Updated: Mar 24, 2026
Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage
Published on: August 4, 2021
[Immunomorphological aspects of miscarriage at late gestational ages]
O P Saryeva1, L M Salakhova1, L V Kulida1
1Laboratory of Pathomorphology and Electron Microscopy, V.N. Gorodkov Ivanovo Research Institute of Maternity and Childhood, Ministry of Health of Russia, Ivanovo, Russia.
Aim:
to reveal the morphological features of placentas and to define a role of the lectin pathway for activation of the complement system in the development of premature birth.
Material And Methods:
A complex morphological study was conducted to examine 37 placentas, 25 of which were obtained from women with clinical signs of threatened miscarriage and 12 placentas from apparently healthy pregnant women.
Results:
Placental tissue CD59 expression was ascertained to be significantly less in the women with threatened miscarriage than in those having full-term babies.
Conclusion:
Decreased CD59 expression in threatened miscarriage at late gestational ages leads to additional activation of a maternal immune response and serves as a possible predictor for premature birth.
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