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CNR improvement of MP2RAGE from slice encoding directional acceleration.

Wanyong Shin1, Taehoon Shin2, Se-Hong Oh1

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|March 17, 2016
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Summary

Accelerated 2D MP2RAGE at 7T improves contrast-to-noise ratio (CNR) by increasing the flip angle. This method enhances brain tissue differentiation and reduces scan time compared to 1D accelerated MP2RAGE.

Keywords:
2D acceleration7TMP2RAGEMPRAGESPIRiTultra-high filed

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Area of Science:

  • Magnetic Resonance Imaging
  • Neuroimaging Techniques
  • Quantitative MRI

Background:

  • MP2RAGE is valuable for B1-insensitive T1 contrast.
  • Long repetition time (TR) in MP2RAGE is crucial for dual inversion time acquisitions.
  • Achieving high-quality imaging with reduced scan times is a key challenge in MRI.

Purpose of the Study:

  • To present a 2D accelerated MP2RAGE technique at 7T.
  • To investigate the impact of increased flip angle and reduced TR on image quality.
  • To compare the performance of 2D accelerated MP2RAGE with 1D accelerated MP2RAGE.

Main Methods:

  • Simulations were performed to optimize 2D accelerated MP2RAGE parameters.
  • Healthy subjects were scanned at 7T using both 1D and 2D accelerated MP2RAGE sequences.
  • Image quality was assessed through visual comparison and measurement of contrast-to-noise ratio (CNR) between brain tissues.

Main Results:

  • Simulations indicated TR and partition encoding steps significantly influence CNR.
  • Keeping TR constant, reducing partition encoding steps enhances maximal achievable CNR.
  • In-vivo 2D accelerated MP2RAGE demonstrated a 9% CNR improvement between white and gray matter compared to 1D accelerated MP2RAGE at identical voxel size.

Conclusions:

  • 2D accelerated MP2RAGE at 7T, with an increased flip angle, effectively improves CNR.
  • This enhancement in CNR allows for a reduction in overall scan time.
  • The presented technique offers a more efficient approach to quantitative MRI.