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Non-directed, carbonate-mediated C-H activation and aerobic C-H oxygenation with Cp*Ir catalysts
1Department of Chemistry & Biochemistry, Worcester Polytechnic Institute, 100 Institute Road, Worcester, MA 01609, USA. mhemmert@wpi.edu and Chemistry Department, Worcester State University, 486 Chandler Street, Worcester, MA 01602, USA.
Abstract:
The effect of oxidatively stable L- and X-type additives on the activity of Cp*Ir catalyst precursors in the C-H activation of arenes has been studied. Turnover numbers for C-H activation of up to 65 can thus be achieved, as determined by H/D exchange in MeOH-D4. In particular, carbonate additives are found to enhance the C-H activation reactivity of Cp*Ir(H2O)3(OTf)2 () more significantly than L-type ligands investigated in this study. Based on these studies, Cp*Ir/carbonate systems are developed that catalyze the aerobic Csp(3)-H oxygenation of alkyl arenes, employing air as oxidant.
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