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Serum Galectin and Renal Dysfunction in ST-Segment Elevation Myocardial Infarction

Victoria Karetnikova1, Anastasia Osokina1, Olga Gruzdeva2

  • 1Federal State Budgetary Institution "Research Institute for Complex Issues of Cardiovascular Diseases", 6 Sosnovy Boulevard, Kemerovo 650002, Russia; Federal State Budget Educational Institution of Higher Professional Education "Kemerovo State Medical Academy of the Ministry of Health of the Russian Federation", 22a Voroshilov Street, Kemerovo 650029, Russia.

Disease Markers
|March 17, 2016
PubMed

Insights

Serum galectin levels and renal dysfunction predict poor prognosis in ST-elevated myocardial infarction (STEMI) patients one year post-event. Elevated galectin correlates with early post-infarction angina, indicating higher risk.

Area of Science:

  • Cardiology
  • Nephrology
  • Biomarkers

Background:

  • ST-elevated myocardial infarction (STEMI) poses significant risks for both cardiac and renal health.
  • Renal dysfunction is an established predictor of adverse outcomes following STEMI.
  • The role of specific biomarkers like galectin in predicting prognosis in STEMI patients with renal dysfunction requires further elucidation.

Purpose of the Study:

  • To investigate the association between serum galectin levels and renal dysfunction.
  • To evaluate the predictive value of galectin and renal function for in-hospital and one-year prognosis after STEMI.
  • To explore the correlation between elevated galectin levels and early postinfarction angina.

Main Methods:

  • Patients with STEMI were stratified into two groups based on cystatin C-estimated glomerular filtration rate (GFR) on day 12: normal GFR (≥60 mL/min/1.73 m²) and renal dysfunction (RD) (<60 mL/min/1.73 m²).
  • GFR was also estimated using the CKD-EPI equation.
  • Serum galectin levels were measured, and a cut-off value of 17.8 ng/mL was used.

Main Results:

  • A decrease in CKD-EPI estimated GFR was more frequent in patients with RD (41.9%) compared to those with normal renal function (21.3%).
  • Elevated galectin levels (>17.8 ng/mL) were observed in 50.6% of patients with RD versus 32% in the normal GFR group.
  • Both RD and elevated galectin levels independently predicted an adverse one-year prognosis in STEMI patients.
  • Elevated galectin levels showed a direct correlation with early postinfarction angina.

Conclusions:

  • Renal dysfunction and elevated serum galectin levels are independent predictors of adverse prognosis one year after STEMI.
  • Galectin may serve as a valuable biomarker for risk stratification in STEMI patients, particularly those with compromised renal function.
  • The findings highlight the intricate relationship between cardiac events, renal health, and systemic inflammation indicated by galectin.

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