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Updated: Mar 24, 2026

Detrusor Underactivity Model in Rats by Conus Medullaris Transection
Published on: August 28, 2020
How botulinum toxin in neurogenic detrusor overactivity can reduce upper urinary tract damage?
Maximilien Baron1, Philippe Grise1, Jean-Nicolas Cornu1
1Maximilien Baron, Philippe Grise, Jean-Nicolas Cornu, Department of Urology, Rouen University Hospital, 76031 Rouen Cedex 1, France.
Abstract:
Intradetrusor injections of botulinum toxin are the cornerstone of medical treatment of neurogenic detrusor overactivity. The primary aim of this treatment is to ensure a low pressure regimen in the urinary bladder, but the mechanisms leading to long-term protection of the urinary tract remain poorly understood. In this paper, we highlight the potential benefits of intradetrusor injections of botulinum toxin regarding local effects on the bladder structures, urinary tract infections, stone disease, vesico ureteral reflux, hydronephrosis, renal function based on a comprehensive literature review.
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