Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Phagocytosis00:41

Phagocytosis

96.0K
Cells pull particles inward and engulf them in spherical vesicles in an energy-requiring process called endocytosis. Phagocytosis (“cellular eating”) is one of three major types of endocytosis. Cells use phagocytosis to take in large objects—such as other cells (or their debris), bacteria, and even viruses.
96.0K
Phagocytosis00:41

Phagocytosis

8.8K
Cells pull particles inward and engulf them in spherical vesicles in an energy-requiring process called endocytosis. Phagocytosis ("cellular eating") is one of three major types of endocytosis. Cells use phagocytosis to take in large objects, such as other cells (or their debris), bacteria, and even viruses.
The objective of phagocytosis is often destruction. Cells use phagocytosis to eliminate unwelcome visitors, like pathogens (e.g., viruses and bacteria). Many immune system cells,...
8.8K
Immune Surveillance by NK Cells and Phagocytes01:25

Immune Surveillance by NK Cells and Phagocytes

9.4K
Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
9.4K
Phagocytosis of Apoptotic Cells01:17

Phagocytosis of Apoptotic Cells

5.5K
Cells undergoing apoptosis form apoptotic bodies that must be removed immediately to prevent inflammation, autoimmune diseases, and necrosis. Phagocytosis is carried out by professional phagocytes such as macrophages or  immature dendritic cells. Non-professional phagocytes such as  epithelial cells and fibroblasts also take part in this process; however, they are not as effective as professional phagocytes. 
Normal cells contain receptors that prevent them from being recognized...
5.5K
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

3.4K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
3.4K
Antigen Presenting Cells01:22

Antigen Presenting Cells

4.2K
The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...
4.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Macrophages in embryonic development.

Nature reviews. Immunology·2026
Same author

Class A scavenger receptor MARCO negatively regulates Ace expression and aldosterone production.

eLife·2025
Same author

F4/80, the plasma membrane antigen of mouse macrophages, an historic journey.

Journal of leukocyte biology·2025
Same author

Class A Scavenger Receptor MARCO negatively regulates Ace expression and aldosterone production.

bioRxiv : the preprint server for biology·2025
Same author

Diminished placental Factor XIIIA1 expression associates with pre-conception antiretroviral treatment and preterm birth in pregnant people living with HIV.

bioRxiv : the preprint server for biology·2024
Same author

A historical perspective of Kupffer cells in the context of infection.

Cell and tissue research·2024
Same journal

Targeting cholesterol esterification sensitizes liver cancer to CD8<sup>+</sup> T cell attack by impairing metabolic and redox resilience.

Immunity·2026
Same journal

Brain endothelial cells orchestrate a neuroprotective antiviral state in the CNS in response to peripheral viral pattern sensing.

Immunity·2026
Same journal

Extracellular ATP-P2RY2 signaling drives intratumoral prostaglandin E2 accumulation and adaptive resistance to immunotherapy in solid tumors.

Immunity·2026
Same journal

B cell-derived type I interferon sustains T cell functionality upon strong TCR stimulation during chronic infection.

Immunity·2026
Same journal

Lactate binds and inhibits the innate immune sensor STING to promote tumor immune evasion.

Immunity·2026
Same journal

Antibody binding geometry and affinity control inhibitory hFcγRIIB receptor signaling.

Immunity·2026
See all related articles

Related Experiment Video

Updated: Mar 24, 2026

Visualizing the Early Stages of Phagocytosis
08:04

Visualizing the Early Stages of Phagocytosis

Published on: February 3, 2017

17.5K

Phagocytosis: An Immunobiologic Process.

Siamon Gordon1

  • 1Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan City 33302, Taiwan; Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK.

Immunity
|March 17, 2016
PubMed
Summary
This summary is machine-generated.

Phagocytosis, crucial for cellular immunity, inflammation, and tissue repair, has been studied for a century. Advances in molecular biology enhance our understanding of its role in health and disease.

More Related Videos

Exploring the Sequential Cellular Events of Phagocytosis Triggered by Godanti Bhasma in Mammalian Cells
10:10

Exploring the Sequential Cellular Events of Phagocytosis Triggered by Godanti Bhasma in Mammalian Cells

Published on: July 11, 2025

834
"Phagosome Closure Assay" to Visualize Phagosome Formation in Three Dimensions Using Total Internal Reflection Fluorescent Microscopy TIRFM
10:07

"Phagosome Closure Assay" to Visualize Phagosome Formation in Three Dimensions Using Total Internal Reflection Fluorescent Microscopy TIRFM

Published on: August 26, 2016

7.1K

Related Experiment Videos

Last Updated: Mar 24, 2026

Visualizing the Early Stages of Phagocytosis
08:04

Visualizing the Early Stages of Phagocytosis

Published on: February 3, 2017

17.5K
Exploring the Sequential Cellular Events of Phagocytosis Triggered by Godanti Bhasma in Mammalian Cells
10:10

Exploring the Sequential Cellular Events of Phagocytosis Triggered by Godanti Bhasma in Mammalian Cells

Published on: July 11, 2025

834
"Phagosome Closure Assay" to Visualize Phagosome Formation in Three Dimensions Using Total Internal Reflection Fluorescent Microscopy TIRFM
10:07

"Phagosome Closure Assay" to Visualize Phagosome Formation in Three Dimensions Using Total Internal Reflection Fluorescent Microscopy TIRFM

Published on: August 26, 2016

7.1K

Area of Science:

  • Immunology
  • Cell Biology
  • Pathology

Background:

  • Élie Metchnikoff pioneered the understanding of phagocytosis in cellular immunity.
  • Phagocytosis is fundamental to host response, inflammation, and tissue homeostasis.
  • Cellular uptake of particles was observed across diverse organisms.

Purpose of the Study:

  • Review current knowledge on phagocytosis.
  • Assess phagocytosis's contribution to physiological and pathological processes.
  • Identify future research and therapeutic opportunities.

Main Methods:

  • Review of historical and contemporary research on phagocytosis.
  • Analysis of cellular and molecular biology tools applied to phagocytosis.
  • Examination of receptor function in immunity.

Main Results:

  • Phagocytosis is central to innate and acquired immunity.
  • Receptor function in phagocytosis is key to immune responses.
  • Significant progress has been made in understanding phagocytosis over the past century.

Conclusions:

  • Phagocytosis remains a critical area of immunological research.
  • Further research can unlock new therapeutic targets.
  • Understanding phagocytosis is essential for managing inflammatory and infectious diseases.