Event-related potentials and white matter lesions in bipolar disorder
E F P M Vuurman1, A Honig2, T H Lamers2
11Universiteit Maastricht, Department of Neuropsychology.
Objectives:
To investigate neurophysiological parameters which possibly distinguish subtypes I and II of patients with a bipolar disorder, and contrast the findings with observations from a group of schizophrenic patients and a group of healthy controls.
Methods:
Sixty-six volunteers underwent a MRI scan to determine the number and location of white matter lesions (WSL). A electrophysiological registration was made while all volunteers performed a auditory 'oddball' task, and the amplitude of the resulting P300 wave was compared.
Results:
Earlier reports of higher numbers of WSL in bipolar disorder were not replicated in this study. Subtypes I and II showed a different P300 amplitude and subtype I resembled the results of the schizophrenia group.
Conclusion:
Bipolar patients in remission have a functional brain disorder that is expressed by a change in physiological response to external stimuli.
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