Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

2.1K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.1K
The Tumor Microenvironment02:17

The Tumor Microenvironment

8.1K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
8.1K
The Tumor Microenvironment02:17

The Tumor Microenvironment

3.0K
3.0K
T Cell Types and Functions01:24

T Cell Types and Functions

3.2K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
3.2K
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

17.2K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
17.2K
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

7.9K
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
7.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

SEMA6A inhibits tumor progression and boosts anti-tumor immunity via blocking the ISG15/TGFβ axis in colorectal cancer.

Molecular biomedicine·2026
Same author

MAGa: Monoclonal Autoimmune Gammopathies.

Cancers·2026
Same author

Regulation of neuronal invasion of small cell lung cancer by STMN2/β-alanine-controlled metabolic reprogramming.

Cell reports·2026
Same author

CD4+ T cells in Type 1 Diabetes: Inferring Stage-specific Dysregulation from scRNA-seq.

Genomics, proteomics & bioinformatics·2026
Same author

Analysis of HERV-K (HML2) Expression in Colorectal Cancer Samples.

Epigenomes·2026
Same author

Single-Cell RNA-Seq Profiling of Transposable Element Expression in Human Peripheral Blood Cells During Viral Infections.

International journal of molecular sciences·2026
Same journal

R-5780, a SagA-engineered Lactococcus lactis, is a safe oral synthetic-biology microbial therapy that potentiates PD-1 blockade.

Cancer immunology, immunotherapy : CII·2026
Same journal

Downregulation of ANKRD22 promotes ovarian cancer cell proliferation by enhancing the immunosuppressive capacity of M-MDSCs.

Cancer immunology, immunotherapy : CII·2026
Same journal

The microbiota-lymphocyte protective axis (MLPA): a novel paradigm for overcoming radiation-induced lymphopenia (RIL) and potentiating the efficacy of tumor immuno-combination therapy.

Cancer immunology, immunotherapy : CII·2026
Same journal

Timing of immune checkpoint inhibitors infusion and prognosis in recurrent/metastatic nasopharyngeal carcinoma: a single-center, retrospective study.

Cancer immunology, immunotherapy : CII·2026
Same journal

CD68<sup>+</sup> tumor-associated macrophages exhibit prognostic value in surgically resected small cell lung cancer: a retrospective cohort study of 614 patients.

Cancer immunology, immunotherapy : CII·2026
Same journal

Regulatory B-cell states in NSCLC immunotherapy resistance: mechanisms, spatial context and translational implications.

Cancer immunology, immunotherapy : CII·2026
See all related articles

Related Experiment Video

Updated: Mar 24, 2026

Preparation of Tumor Antigen-loaded Mature Dendritic Cells for Immunotherapy
08:40

Preparation of Tumor Antigen-loaded Mature Dendritic Cells for Immunotherapy

Published on: August 1, 2013

18.8K

Tumor-derived factors modulating dendritic cell function.

Jinbao Zong1,2, Anton A Keskinov1, Galina V Shurin1

  • 1Department of Pathology, University of Pittsburgh Medical Center, Scaife Hall S735, 3550 Terrace Street, Pittsburgh, PA, 15261, USA.

Cancer Immunology, Immunotherapy : CII
|March 18, 2016
PubMed
Summary
This summary is machine-generated.

Dendritic cells (DCs) are crucial in cancer immunity, either promoting anti-tumor responses or causing immune suppression. Understanding their modulation by tumor factors is key for effective cancer vaccines and therapies.

Keywords:
CytokinesDendritic cellsImmunosuppressionRegulatory dendritic cellsToleranceTumor immunoenvironment

More Related Videos

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine
09:15

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine

Published on: February 24, 2023

4.2K
Tractable In Vivo Reprogramming of Tumor Cells to Type 1 Conventional Dendritic Cell-like Cells
10:04

Tractable In Vivo Reprogramming of Tumor Cells to Type 1 Conventional Dendritic Cell-like Cells

Published on: August 1, 2025

1.9K

Related Experiment Videos

Last Updated: Mar 24, 2026

Preparation of Tumor Antigen-loaded Mature Dendritic Cells for Immunotherapy
08:40

Preparation of Tumor Antigen-loaded Mature Dendritic Cells for Immunotherapy

Published on: August 1, 2013

18.8K
Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine
09:15

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine

Published on: February 24, 2023

4.2K
Tractable In Vivo Reprogramming of Tumor Cells to Type 1 Conventional Dendritic Cell-like Cells
10:04

Tractable In Vivo Reprogramming of Tumor Cells to Type 1 Conventional Dendritic Cell-like Cells

Published on: August 1, 2025

1.9K

Area of Science:

  • Immunology
  • Oncology
  • Cell Biology

Background:

  • Dendritic cells (DCs) are key immune regulators in cancer.
  • DCs influence tumor development, progression, and therapeutic responses.
  • Their dual role involves antigen presentation and immune modulation.

Purpose of the Study:

  • To review the multifaceted roles of dendritic cells in cancer.
  • To explore how tumor and stromal factors modulate DC function.
  • To highlight the importance of understanding DC-environment interactions for cancer immunotherapy.

Main Methods:

  • Literature review of studies on dendritic cells in cancer.
  • Analysis of mechanisms of DC recruitment, maturation, and function in the tumor microenvironment.
  • Discussion of factors influencing DC-mediated anti-tumor immunity and immune suppression.

Main Results:

  • DCs present tumor antigens to T cells, initiating anti-tumor responses.
  • Tumor-derived factors can impair DC function, leading to immune suppression or tolerance.
  • DC interactions with other immune cells impact innate and humoral anti-tumor immunity.

Conclusions:

  • Targeting DC-modulating factors is crucial for enhancing anti-tumor immunity.
  • Understanding DC plasticity is vital for developing effective dendritic cell-based cancer vaccines.
  • Restoring DC function is essential for maintaining clinically relevant anti-tumor immunity in cancer patients.