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Updated: Mar 24, 2026

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
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Discovery of G Protein-Biased EP2 Receptor Agonists

Seiji Ogawa1, Toshihide Watanabe2, Isamu Sugimoto2

  • 1Medicinal Chemistry Research Laboratories, Department of Biology & Pharmacology, and Discovery Research Alliance, Ono Pharmaceutical Co., Ltd., 3-1-1 Sakurai, Shimamoto-cho, Mishima-gun, Osaka 618-8585, Japan; Department of Chemistry, Graduate School of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8571, Japan.

ACS Medicinal Chemistry Letters
|March 18, 2016
PubMed

Keywords:
EP2Prostaglandinagonistbiased ligandstructure−functional selectivity relationship

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