Related Experiment Video
Updated: Mar 24, 2026
In Vitro Imaging and Quantification of the Drug Targeting Efficiency of Fluorescently Labeled GnRH Analogues
Published on: March 21, 2017
A comparison between r-LH and urinary supplements containing LH activity in patients undergoing the microdose GnRH
Tal Shavit1, Mohammed Agdi, Weon Y Son
1McGill Reproductive Center, McGill University, Royal Victoria Hospital, Montreal, Canada - michael.dahan@muhc.mcgill.ca.
Background:
The aim of this study was to compare pregnancy rates and stimulation parameters in patients with diminished ovarian reserve, who were treated with recombinant human luteinizing hormone (r-LH) or menopausal gonadotropins (hMG), as part of a microdose flare protocol.
Methods:
A retrospective cohort study was performed. Comparisons between the group that was stimulated with r-LH plus follicle stimulating hormone (FSH) to those treated with hMG and FSH, were performed. Measurements included: medication doses, number of oocyte collected, number of embryos obtained, pregnancy and clinical pregnancy rates.
Results:
Patients in the r-LH group (N.=40) had significant higher clinical pregnancy rates (33% vs. 14%; P=0.04) and used lower dose of LH (1938 IU vs. 2807 IU; P=0.02) compared to patients that were stimulated with hMG (N.=39).
Conclusions:
r-LH may offer advantages for the treatment of diminished ovarian reserve when performing a microdose flare protocol when compared to hMG. Both larger and prospective studies should be carried out to confirm these findings.
More Related Videos
05:32Author Spotlight: Investigating the Relationship Between FSH and Pathophysiological Changes in Perimenopausal Women - Insights from a Mouse Model
Published on: August 11, 2023
08:56Author Spotlight: Automated Infusion and Blood Sampling for Precise Hormonal Analysis in Conscious Mice
Published on: August 25, 2023