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RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
Published on: April 10, 2018
Long noncoding RNAs and atherosclerosis
Tian Zhou1, Jia-wang Ding1, Xin-an Wang1
1Department of Cardiology, The First College of Clinical Medical Science, China Three Gorges University, Yichang 443000, Hubei Province, China; Institute of Cardiovascular Diseases, China Three Gorges University, Yichang 443000, Hubei Province, China.
Insights
Long noncoding RNAs (lncRNAs) are crucial regulators in atherosclerosis, a chronic inflammatory disease. This review explores how lncRNAs impact vascular wall function, macrophage activity, and lipid metabolism in the context of atherosclerosis.
Area of Science:
- Vascular Biology
- Molecular Medicine
- RNA Biology
Background:
- Atherosclerosis is a chronic inflammatory disease of the vessel wall.
- It is triggered by dyslipidemia and hemodynamic stress.
- Vascular cells and infiltrating leukocytes are key players.
Purpose of the Study:
- To review the role of long noncoding RNAs (lncRNAs) in atherosclerosis.
- To elucidate the regulatory functions of lncRNAs in vascular wall biology.
- To understand lncRNA involvement in macrophage activation, lipid metabolism, and immune responses.
Main Methods:
- Literature review of existing research on lncRNAs and atherosclerosis.
- Analysis of studies investigating lncRNA functions in vascular cells and macrophages.
- Synthesis of evidence linking lncRNAs to key pathological processes in atherosclerosis.
Main Results:
- lncRNAs are nonprotein-coding RNAs involved in diverse biological processes.
- Evidence indicates lncRNAs regulate vascular wall function.
- lncRNAs influence macrophage activation, lipid metabolism, and immune responses relevant to atherosclerosis.
Conclusions:
- lncRNAs play a significant role in the pathogenesis of atherosclerosis.
- Understanding lncRNA regulation offers potential therapeutic targets.
- Further research into lncRNA mechanisms is warranted for atherosclerosis treatment.
Abstract:
Atherosclerosis is universally recognized as a chronic lipid-induced inflammation of the vessel wall in response to dyslipidemia and haemodynamic stress involving dysfunction and activation of resident vascular cells as well as infiltration of leukocytes. As members of nonprotein-coding RNAs, the long noncoding RNAs (lncRNAs) are implicated in various biological processes. Accumulating evidences suggest that lncRNAs regulate the function of vascular wall, activation of macrophages, lipid metabolism and immune response. Here, we review the effects of lncRNAs on the progress of atherosclerosis.
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