Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

10.1K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
10.1K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

3.8K
3.8K
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

1.9K
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
1.9K
Types of RNA01:20

Types of RNA

16.2K
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
16.2K
Types of RNA01:23

Types of RNA

73.8K
Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
73.8K
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

576
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
576

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Laser-Emitting Droplet Assay for Enzymatic Evaluation Applications.

ACS nano·2026
Same author

Cell death crosstalk in NET-Driven inflammation: mechanisms, disease contexts, and therapeutic perspectives.

Biomarker research·2026
Same author

Functional reserve mitigates cognitive-motor dual-task costs in older adults: insights from age, cohort, and behavioural strategies.

European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity·2026
Same author

Acetylcholine in Brain-Body Communication: Biological Mechanisms and Physiological Roles.

International journal of molecular sciences·2026
Same author

Association Between Mind Mapping Combined with Teach-Back and Follow-Up Adherence After Percutaneous Coronary Intervention: An Exploratory Study.

Patient preference and adherence·2026
Same author

Distal Vessel Diameter and Antegrade Crossing Success in Chronic Total Occlusion Percutaneous Coronary Intervention.

CJC open·2026
Same journal

Methodological and clinical considerations in a Japanese cohort study of familial hypercholesterolemia and stroke-authors' reply.

Atherosclerosis·2026
Same journal

Optimized flow cytometry assay for functional characterization of variants of uncertain significance in familial hypercholesterolemia.

Atherosclerosis·2026
Same journal

Causal insights of modifiable cardiovascular risk factors for dementia risk - potential for efficient prevention and improved brain health.

Atherosclerosis·2026
Same journal

Serial OCT-based coronary physiology and plaque composition in vessels with nonobstructive coronary lesions following intensive lipid-lowering therapy: YELLOW III sub-study.

Atherosclerosis·2026
Same journal

Earliest age to detect lifetime cardiometabolic health stratification in children.

Atherosclerosis·2026
Same journal

Sympathetic neurons exacerbate atherosclerosis by modulating macrophage function via the NPY/Y1R axis.

Atherosclerosis·2026
See all related articles

Related Experiment Video

Updated: Mar 24, 2026

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
09:36

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

26.5K

Long noncoding RNAs and atherosclerosis.

Tian Zhou1, Jia-wang Ding1, Xin-an Wang1

  • 1Department of Cardiology, The First College of Clinical Medical Science, China Three Gorges University, Yichang 443000, Hubei Province, China; Institute of Cardiovascular Diseases, China Three Gorges University, Yichang 443000, Hubei Province, China.

Atherosclerosis
|March 18, 2016
PubMed
Summary
This summary is machine-generated.

Long noncoding RNAs (lncRNAs) are crucial regulators in atherosclerosis, a chronic inflammatory disease. This review explores how lncRNAs impact vascular wall function, macrophage activity, and lipid metabolism in the context of atherosclerosis.

Keywords:
AtherosclerosisLipidLong noncoding RNAsVascular functionVascular inflammation

More Related Videos

A Model of Disturbed Flow-Induced Atherosclerosis in Mouse Carotid Artery by Partial Ligation and a Simple Method of RNA Isolation from Carotid Endothelium
11:00

A Model of Disturbed Flow-Induced Atherosclerosis in Mouse Carotid Artery by Partial Ligation and a Simple Method of RNA Isolation from Carotid Endothelium

Published on: June 22, 2010

30.3K

Related Experiment Videos

Last Updated: Mar 24, 2026

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
09:36

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

26.5K
A Model of Disturbed Flow-Induced Atherosclerosis in Mouse Carotid Artery by Partial Ligation and a Simple Method of RNA Isolation from Carotid Endothelium
11:00

A Model of Disturbed Flow-Induced Atherosclerosis in Mouse Carotid Artery by Partial Ligation and a Simple Method of RNA Isolation from Carotid Endothelium

Published on: June 22, 2010

30.3K

Area of Science:

  • Vascular Biology
  • Molecular Medicine
  • RNA Biology

Background:

  • Atherosclerosis is a chronic inflammatory disease of the vessel wall.
  • It is triggered by dyslipidemia and hemodynamic stress.
  • Vascular cells and infiltrating leukocytes are key players.

Purpose of the Study:

  • To review the role of long noncoding RNAs (lncRNAs) in atherosclerosis.
  • To elucidate the regulatory functions of lncRNAs in vascular wall biology.
  • To understand lncRNA involvement in macrophage activation, lipid metabolism, and immune responses.

Main Methods:

  • Literature review of existing research on lncRNAs and atherosclerosis.
  • Analysis of studies investigating lncRNA functions in vascular cells and macrophages.
  • Synthesis of evidence linking lncRNAs to key pathological processes in atherosclerosis.

Main Results:

  • lncRNAs are nonprotein-coding RNAs involved in diverse biological processes.
  • Evidence indicates lncRNAs regulate vascular wall function.
  • lncRNAs influence macrophage activation, lipid metabolism, and immune responses relevant to atherosclerosis.

Conclusions:

  • lncRNAs play a significant role in the pathogenesis of atherosclerosis.
  • Understanding lncRNA regulation offers potential therapeutic targets.
  • Further research into lncRNA mechanisms is warranted for atherosclerosis treatment.