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Updated: Mar 24, 2026

Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis
Published on: March 9, 2018
Two new asterriquinols from Aspergillus sp. CBS-P-2 with anti-inflammatory activity
Xiao An1,2, Bao-Min Feng3, Gang Chen1,2
1a Key Laboratory of Structure-Based Drug Design & Discovery , Ministry of Education, Shenyang Pharmaceutical University , Shenyang 110016 , China.
Abstract:
Two new bisindolylbenzenoid alkaloids asterriquinol E (1) and asterriquinol F (2), together with four known compounds (3-6) were isolated from the fermentation products of the fungus Aspergillus sp. CBS-P-2. Their structures were established on the basis of extensive spectroscopic analysis, including HR-ESI-MS, UV, IR, 1D, and 2D NMR (HSQC, HMBC, and NOESY) methods. The stereochemical structure of 2 was confirmed via the CD data of the in situ formed [Rh2(OCOCF3)4] complex method. All of the isolated compounds were tested for inhibitory activity against LPS (lipopolysaccharide)-induced nitric oxide production in microglia.
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