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Polyketides with anti-inflammatory activity isolated from Rhodiola tibetica endophytic fungus Penicillium sp.
Xuan Lu1, Jun-Kai Qi1, Xiao-Yuan Tang1
1College of Life and Health, Dalian University, Dalian 116622, China.
Abstract:
Seven undescribed polyketide compounds (1-4, 9-11) and six known polyketide compounds (5-8,12, 13) were isolated from Rhodiola tibetica endophytic Penicillium sp. HJT-A-10. The structural of seven undescribed polyketides metabolites were established on the basis of spectroscopic methods. The results of anti-inflammatory activity showed that compounds 1-8，10-13 had significant inhibitory effects on LPS-induced NO production in RAW 264.7 cells.
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