Evaluation of CIEP and ELISA in a rodent malaria model

Circulating antigens could be detected by both ELISA and CIEP in the sera of mice infected with Plasmodium berghei. However, ELISA was positive for circulating antigen even though the Giemsa stained smears did not show significant parasites. Hence, ELISA can have a diagnostic value for detection of antigens as a marker of active infection.