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No associations between five polymorphisms in COMT gene and migraine.

H Takigawa1, H Kowa1, K Nakashima1

  • 1Division of Neurology, Department of Brain and Neurosciences, Faculty of Medicine, Tottori University, Yonago, Japan.

Acta Neurologica Scandinavica
|March 19, 2016
PubMed
Summary

This study found no link between COMT gene variations and chronic headaches in Western Japan. Further research is needed to explore other parts of the COMT gene for potential migraine associations.

Keywords:
dopaminehaplotypemigrainepainsingle nucleotide polymorphisms

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Area of Science:

  • Neuroscience
  • Genetics
  • Pharmacogenomics

Background:

  • Migraine pathophysiology remains unclear, with the dopaminergic system implicated.
  • Catechol-O-methyltransferase (COMT) enzyme activity influences neurotransmitter levels.

Purpose of the Study:

  • To investigate the association between COMT gene polymorphisms and chronic headaches.
  • To analyze five single nucleotide polymorphisms (SNPs) in the COMT gene.

Main Methods:

  • Genotyping of five COMT SNPs (rs4633, rs6267, rs4680, rs6270, rs740602) in 71 migraine with aura, 152 migraine without aura, 86 tension-type headache patients, and 191 controls.
  • Analysis of genotypes, allele frequencies, and haplotypes.

Main Results:

  • No significant differences were observed in genotypes, allele frequencies, or haplotypes among patient groups and healthy controls.
  • The studied COMT polymorphisms showed no association with migraine or tension-type headache.

Conclusions:

  • The five investigated COMT polymorphisms are not associated with migraine in the Western Japan population.
  • Further investigation into other COMT gene segments or regulatory elements is warranted.
  • The COMT gene cannot be entirely excluded from migraine pathogenesis.