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ABO blood group system and the coronary artery disease: an updated systematic review and meta-analysis

Zhuo Chen1,2, Sheng-Hua Yang1, Hao Xu3

  • 1Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, BeiLiShi Road 167, Beijing 100037, China.

Scientific Reports
|March 19, 2016
PubMed

Insights

Individuals with blood group A have an increased risk of coronary artery disease (CAD), while those with blood group O have a reduced risk. This meta-analysis confirms ABO blood type as a significant factor in CAD development.

Area of Science:

  • Genetics
  • Cardiovascular Medicine
  • Epidemiology

Background:

  • The ABO blood group system is a known genetic risk factor for thrombotic vascular diseases.
  • The association between ABO blood groups and coronary artery disease (CAD) remains a subject of debate.

Purpose of the Study:

  • To conduct an updated meta-analysis to clarify the role of ABO blood groups as a risk factor for CAD.
  • To investigate the association between specific ABO blood types and the risk of developing CAD.

Main Methods:

  • A systematic review and meta-analysis of case-control and cohort studies.
  • Searched PubMed, Embase, and Cochrane Library for relevant studies.
  • Included 17 studies with a total of 225,810 participants.

Main Results:

  • Blood group A was associated with a significantly higher risk of CAD (OR = 1.14).
  • Blood group O was associated with a significantly lower risk of CAD (OR = 0.85).
  • These associations remained significant even after excluding studies focused solely on myocardial infarction (MI).

Conclusions:

  • The ABO blood group system is a significant risk factor for coronary artery disease.
  • Blood group A is identified as a risk factor, while non-O blood groups, particularly O, show a protective effect against CAD.

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