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[Immunopathology of glomerulonephritis with mesangial IgA deposits]
1Service de Néphrologie, dialyse et transplantation rénale, Hôpital Nord, CHU de Saint-Etienne.
Nephrologie
|January 1, 1989
Abstract:
IgA nephropathy is the most frequent type of glomerulonephritis in France. Its definition is on renal pathology. Mesangial IgA deposits are dimeric or polymeric and probably from secretory origin. Circulating IgA molecules correspond to immune complexes with unknown antigens. The IgA subclass remains still controversial: exclusive IgA1 versus IgA1 and IgA2. The pathogenesis of the disease is based on an immune defect specific of the secretory IgA system and eventually of the serum IgA system. The human disease can be experimentally reproduced. Nevertheless, numerous unknown explanations persist in this disease.