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Decreased MALL expression negatively impacts colorectal cancer patient survival
Xiaoliang Wang1, Junwei Fan1, Fudong Yu1
1Department of General Surgery, Shanghai First People's Hospital, Medical College, Shanghai Jiao Tong University, Shanghai, China.
Abstract:
The aim of the present study was to determine whether MALL expression is associated with colon cancer progression and patient survival. MALL mRNA expression was reduced in the tumor tissues of 70% of the colon cancer patients and 75% of the rectal cancer patients as compared to their normal tissues. MALL protein was also significantly reduced in the tumor tissues of colon cancer patients (P < 0.001). Increased LOH and methylation of MALL was observed in tumor tissues as compared to normal tissues. Reduced MALL expression was associated with vessin invasion, disease recurrence and metastasis or death (P ≤ 0.027). Furthermore, patients with MALL-negative tumors had significantly decreased overall survival (OS) and disease-free survival (DFS) (P < 0.008 and P < 0.011, respectively). Univariate analysis indicated that MALL expression was significantly associated with OS and DFS. Finally, overexpression of MALL suppressed HCT116 and SW480 cell proliferation and inhibited HCT116 migration. MALL may play a role in colorectal cancer progression as suppression of its expression in tumor tissues negatively impacts colorectal cancer patient survival. Further analyses are required to determine if reduced MALL expression is due to LOH and/or methylation.
Insights
Reduced MALL expression is linked to poorer outcomes in colon cancer patients, including increased metastasis and decreased survival. MALL may act as a tumor suppressor in colorectal cancer progression.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- MALL (mucin-associated لیگ্যান্ড) is a gene implicated in cellular processes.
- Its role in colorectal cancer (CRC) progression and patient prognosis remains unclear.
Purpose of the Study:
- To investigate the association between MALL expression and colon cancer progression.
- To evaluate the impact of MALL expression on patient survival in colorectal cancer.
Main Methods:
- Quantitative analysis of MALL mRNA and protein expression in tumor versus normal tissues.
- Assessment of Loss of Heterozygosity (LOH) and methylation of MALL in tumor tissues.
- Correlation analysis of MALL expression with clinical parameters like invasion, recurrence, metastasis, and survival.
- In vitro studies involving MALL overexpression in colon cancer cell lines (HCT116, SW480) to assess proliferation and migration.
Main Results:
- MALL mRNA and protein expression were significantly reduced in 70-75% of colon and rectal cancer tissues compared to normal tissues.
- Increased LOH and methylation of MALL were observed in tumor tissues.
- Reduced MALL expression correlated significantly with vascular invasion, disease recurrence, metastasis, and mortality (P ≤ 0.027).
- Patients with MALL-negative tumors exhibited significantly decreased overall survival (OS) and disease-free survival (DFS) (P < 0.008 and P < 0.011, respectively).
- Overexpression of MALL suppressed HCT116 and SW480 cell proliferation and inhibited HCT116 cell migration.
Conclusions:
- MALL expression is significantly downregulated in colorectal cancer tissues.
- Reduced MALL expression is associated with aggressive tumor features and poorer patient survival (OS and DFS).
- MALL may function as a tumor suppressor in colorectal cancer, and its reduced expression negatively impacts patient prognosis.
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