Hypoglycaemia associated to vaginal insulin placement in rats

The effect of vaginal placement of insulin was ascertained in rats by measuring plasma glucose levels. A rapid and sustained decrease of plasma glucose levels at 30, 60, 90 and 120 minutes after vaginal insulin administration was observed, returning to basal levels by 240 minutes. Thus, rapid insulin absorption was not curtailed by vaginal mucose. The effect was independent of the rat oestrous cycle phase.