Related Experiment Video
Updated: Mar 24, 2026
08:56
Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats
Published on: April 7, 2023
1.5K
Effects of bariatric surgery on bone
1Département des spécialités de médecine, service des maladies osseuses, hôpitaux universitaires, faculté de médecine de Genève, 4, rue Gabrielle-Perret-Gentil, 1205 Geneva, Switzerland.
Joint Bone Spine
|March 20, 2016
Summary
Bariatric surgery may impact bone density, but fracture risk appears similar to obese patients. Quantitative CT is more accurate than DXA for measuring bone mineral density post-surgery.
Area of Science:
- Endocrinology
- Orthopedics
- Metabolic Surgery
Background:
- Bariatric surgery combines restrictive and malabsorptive techniques.
- Early bone mineral density (BMD) decreases are noted post-surgery.
- Weight loss can affect BMD measurement accuracy.
Purpose of the Study:
- To evaluate bone mineral density (BMD) changes after bariatric surgery.
- To compare BMD measurement accuracy between DXA and QCT.
- To assess fracture incidence in bariatric surgery patients.
Main Methods:
- Utilized quantitative computed tomography (QCT) for BMD assessment.
- Monitored bone resorption markers and hormonal changes.
- Compared fracture rates with non-operated obese individuals.
Main Results:
- Quantitative CT (QCT) offers more reliable BMD measurements than DXA post-weight loss.
- Nutritional deficiencies and hormonal shifts correlate with increased bone resorption markers.
- Limited data suggest fracture incidence is not elevated compared to obese controls.
Conclusions:
- QCT is preferred for BMD monitoring after bariatric procedures.
- Bone metabolism is significantly altered by bariatric surgery.
- Current evidence does not indicate increased fracture risk post-bariatric surgery.
Related Concept Videos
01:29Bone Disorders
6.8K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
6.8K
01:40Bone Remodeling
41.0K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
41.0K
01:17Hormones and Bone Tissue
4.2K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
4.2K
01:25Role of Vitamins in Maintaining Bone Health
6.0K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
6.0K
01:31Osteoclasts in Bone Remodeling
4.7K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
4.7K
01:31Essential Minerals for Bone Health
7.1K
The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
7.1K