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Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
Published on: January 28, 2020
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Biomarkers for post-thrombotic syndrome
Annemieke C Bouman1, Selma Atalay2, Hugo Ten Cate1
1Laboratory for Thrombosis and Hemostasis, Department of Internal Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands.
Journal of Vascular Surgery. Venous and Lymphatic Disorders
|March 20, 2016
Summary
Increased D-dimer levels double the risk of post-thrombotic syndrome (PTS) after deep venous thrombosis (DVT). While inherited hypercoagulability like factor V Leiden (FVL) isn't generally linked to PTS, it strongly correlates with severe post-thrombotic ulceration.
Area of Science:
- Vascular Medicine
- Hematology
- Biomarker Research
Background:
- Post-thrombotic syndrome (PTS) affects 20%-50% of patients after deep venous thrombosis (DVT).
- Biomarkers are crucial for understanding PTS etiology and developing risk stratification tools.
- Identifying biomarker-PTS relationships can guide personalized prevention and therapy strategies.
Purpose of the Study:
- To review current knowledge on biomarkers associated with post-thrombotic syndrome (PTS).
- To evaluate the role of specific biomarkers in the development and severity of PTS following DVT.
- To synthesize findings from existing literature on biomarker-PTS associations.
Main Methods:
- Systematic literature search across PubMed, Embase/Medline, and Cochrane databases.
- Inclusion of publications specifically on biomarkers in relation to PTS.
- Meta-analysis performed on pooled study results where feasible using Review Manager 5.1.
Main Results:
- Twenty-four studies were included in the review.
- Elevated D-dimer levels showed a significant association with PTS development (OR, 2.04).
- Factor V Leiden (FVL) was not associated with general PTS but strongly linked to post-thrombotic ulceration (OR, 11.42).
Conclusions:
- Increased D-dimer is associated with a twofold higher risk of PTS.
- Inherited hypercoagulability, including FVL, is not generally linked to PTS.
- FVL is strongly associated with severe PTS complications like ulceration; inflammation's role requires further study.
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