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Fundamental developments in infrared spectroscopic imaging for biomedical applications
Michael Pilling1, Peter Gardner
1Manchester Institute of Biotechnology, University of Manchester, 131 Princess Street, Manchester, M1 7DN, UK. Peter.Gardner@Manchester.ac.uk.
Chemical Society Reviews
|March 22, 2016
Summary
Infrared chemical imaging, or spectral histopathology (SHP), offers a promising new method for disease diagnosis by analyzing biochemical signatures. This technology has the potential to revolutionize traditional histopathology, improving diagnostic accuracy.
Area of Science:
- Biomedical Optics
- Chemical Imaging
- Spectroscopy
Background:
- Infrared chemical imaging is advancing rapidly in instrumentation and data analysis.
- Biomedical applications show promise for improved disease diagnosis.
- Current methods often rely on exogenous dyes, limiting specificity.
Purpose of the Study:
- To review recent advances in infrared spectroscopic imaging for spectral histopathology (SHP).
- To assess the current state and practical applications of SHP in disease diagnosis.
- To identify barriers and future directions for clinical translation.
Main Methods:
- Review of recent literature on infrared spectroscopic imaging.
- Focus on spectral histopathology (SHP) techniques.
- Analysis of biochemical signatures for disease detection.
Main Results:
- Significant advances in instrumentation, data acquisition, and analysis.
- Demonstrated potential for improved disease diagnosis without exogenous contrast agents.
- SHP offers a revolutionary approach to histopathology.
Conclusions:
- Infrared chemical imaging, specifically SHP, holds great promise for revolutionizing disease diagnosis.
- Addressing practical application barriers is crucial for clinical translation.
- Continued research and development will shape the future outlook of SHP.
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