[Correlation between post-cholecystectomy syndrome and biliary reflux gastritis. Endoscopic study]

Area of Science:

• Gastroenterology
• Pathology

Background:

• Bile acids are known to damage gastric mucosa.
• Duodenogastric reflux affects 20-30% of individuals post-cholecystectomy.

Purpose of the Study:

• To determine the correlation between duodenogastric reflux-induced gastric mucosa damage and post-cholecystectomy syndrome.
• To investigate the association between biliary reflux and histological findings of gastritis.

Main Methods:

• Comparison of two groups: 14 symptomatic and 14 asymptomatic post-cholecystectomy patients.
• Endoscopic examination (EGDS) with biopsy and 99Tc HIDA cholescintigraphy.

Main Results:

• 85% of symptomatic patients showed bile reflux and antral inflammation versus 7.14% of controls.
• Active chronic gastritis was found in 90% of symptomatic patients compared to 0% of asymptomatic patients.
• Atrophic chronic gastritis was more prevalent in symptomatic (71.43%) versus asymptomatic (14.28%) patients.

Conclusions:

• A positive correlation exists between duodenogastric reflux and post-cholecystectomy syndrome.
• Biliary reflux is strongly associated with histological findings of active chronic gastritis in the antrum.