Related Experiment Video
Updated: Mar 24, 2026
03:26
Detrusor Underactivity Model in Rats by Conus Medullaris Transection
Published on: August 28, 2020
2.4K
Systemic Nonurological Symptoms in Patients with Overactive Bladder.
H Henry Lai1, Joel Vetter2, Sanjay Jain3
1Division of Urologic Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, Missouri; Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri.
The Journal of Urology
|March 22, 2016
Summary
Patients with overactive bladder (OAB) experience significantly more nonurological symptoms than controls, indicating a potential systemic cause for OAB. Widespread systemic symptoms in OAB patients correlate with poorer quality of life and increased psychosocial difficulties.
Area of Science:
- Urology
- Internal Medicine
- Psychosomatic Medicine
Background:
- Overactive bladder (OAB) is typically viewed as a urological condition.
- The potential contribution of systemic (nonurological) symptoms to OAB pathophysiology is not well understood.
Purpose of the Study:
- To compare systemic symptoms between patients with OAB and controls.
- To investigate the association between systemic symptom burden and urinary symptoms, quality of life, and psychosocial measures in OAB patients.
Main Methods:
- A polysymptomatic questionnaire assessed systemic symptoms in 51 OAB patients and 30 controls.
- Validated instruments measured urinary symptoms, quality of life, and psychosocial factors.
- OAB patients were subgrouped based on the presence of widespread systemic symptoms.
Main Results:
- OAB patients reported significantly more systemic symptoms (17.5 vs 6.4, p <0.001) across multiple organ systems.
- Approximately one-third of OAB patients had widespread systemic symptoms (mean 32.0 symptoms).
- Widespread systemic symptoms correlated with worse OAB/incontinence symptoms, reduced quality of life, and increased depression, anxiety, and fatigue.
Conclusions:
- Increased nonurological symptoms in OAB suggest an underlying systemic etiology.
- Systemic factors may play a significant role in the development and manifestation of OAB.
- Understanding systemic involvement is crucial for managing OAB and other urological conditions.
Related Concept Videos
01:18Disorders of the Autonomic Nervous System
1.9K
The autonomic nervous system (ANS) is an intricate network of nerves that controls functions such as the regulation of heart rate, digestion, and blood pressure regulation. When this system malfunctions, it can lead to various disorders that affect multiple bodily functions. One common feature of many autonomic disorders is the involvement of smooth blood vessels, which play a crucial role in regulating blood flow throughout the body.
Raynaud's disease, also known as Raynaud's...
Raynaud's disease, also known as Raynaud's...
1.9K
01:20Disorders of the Urinary System
1.9K
The urinary system is responsible for eliminating waste and excess fluids from the body. However, disorders of the urinary system can arise due to various reasons like infections, stress, age, congenital abnormalities, and lifestyle.
Urinary tract infections (UTIs) are one of the most common urinary system disorders. They are caused by bacteria that enter the urethra and can spread to the bladder resulting in cystitis. Pyelonephritis is the result of a UTI that has ascended to the level of the...
Urinary tract infections (UTIs) are one of the most common urinary system disorders. They are caused by bacteria that enter the urethra and can spread to the bladder resulting in cystitis. Pyelonephritis is the result of a UTI that has ascended to the level of the...
1.9K
01:26The Micturition Reflex
3.5K
Urination, or micturition involves the coordination of the bladder's detrusor muscle and two sphincters to ensure controlled bladder emptying.
The process begins with bladder filling, where the bladder wall stretches as urine accumulates. This stretching activates the urine storage reflex, mediated by the sacral spinal segments and the pontine storage center. Efferent sympathetic impulses stimulate the detrusor muscle to relax and the internal urethral sphincter to contract, facilitating...
The process begins with bladder filling, where the bladder wall stretches as urine accumulates. This stretching activates the urine storage reflex, mediated by the sacral spinal segments and the pontine storage center. Efferent sympathetic impulses stimulate the detrusor muscle to relax and the internal urethral sphincter to contract, facilitating...
3.5K
01:23Urinary Bladder
4.2K
The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
4.2K
01:26Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations
599
Renal calculi, commonly termed kidney stones, are crystalline solid masses that form in the kidneys but can occur at any point within the urinary system, encompassing the kidneys, ureters, bladder, and urethra.The pathophysiology of renal stones involves several key factors: supersaturation of the urine with stone-forming constituents, changes in urine pH, a decrease in urine volume, and the presence of substances that promote or inhibit stone formation.Supersaturation of Urine: This is the...
599
01:21Nursing Assessment of the Genitourinary System I: Health History
559
The genitourinary system is critical to maintaining fluid balance, waste elimination, and reproductive function. Nurses play a vital role in assessing this system, beginning with a thorough health history. This process involves gathering patient information, identifying risk factors, and recognizing symptoms of genitourinary disorders. Early detection is vital for timely interventions and management.1. Gathering Patient InformationA complete health history includes the patient’s personal,...
559