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Related Experiment Video

Updated: Mar 23, 2026

Synthesis of Multi-walled Carbon Nanotubes Modified with Silver Nanoparticles and Evaluation of Their Antibacterial Activities and Cytotoxic Properties

Synthesis of Multi-walled Carbon Nanotubes Modified with Silver Nanoparticles and Evaluation of Their Antibacterial Activities and Cytotoxic Properties

Published on: May 10, 2018

Polyethyleneimine Capped Silver Nanoclusters as Efficient Antibacterial Agents.

Dong Xu¹, Qingyun Wang², Tao Yang³

¹National Engineering Laboratory for Rice and By-Products Further Processing, Central South University of Forestry & Technology, Changsha 410004, China. philip198349@gmail.com.

International Journal of Environmental Research and Public Health

|March 22, 2016

Summary

Polyethyleneimine (PEI)-capped silver nanoclusters (PEI-AgNCs) show excellent antibacterial activity. Lowering PEI molecular weight enhances the antibacterial capacity of these novel nanoclusters for clinical use.

Keywords:

antibacterial agent polyethyleneimine silver nanoclusters

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Last Updated: Mar 23, 2026

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Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro

Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro

Published on: April 21, 2023

Area of Science:

Materials Science
Nanotechnology
Microbiology

Background:

Developing effective antibacterial agents is crucial for public health.
Silver nanoclusters (AgNCs) offer high surface-to-volume ratios for enhanced activity.
Polyethyleneimine (PEI) possesses inherent antimicrobial properties.

Purpose of the Study:

To synthesize and characterize PEI-capped silver nanoclusters (PEI-AgNCs).
To investigate the antibacterial activity of PEI-AgNCs with varying PEI molecular weights.
To evaluate the potential of PEI-AgNCs as clinical antibacterial agents.

Main Methods:

Synthesis of PEI-AgNCs using PEI with molecular weights ranging from 0.6 kDa to 25 kDa.
Characterization using UV-Vis absorption, fluorescence spectroscopy, and high-resolution transmission electron microscopy (HRTEM).
Assessment of antibacterial activity in both agar plate and liquid culture systems.

Main Results:

Stable PEI-AgNCs with sizes around 2 nm were successfully synthesized.
Nanocluster size was largely independent of PEI molecular weight.
PEI-AgNCs demonstrated excellent antibacterial activity, which increased as PEI molecular weight decreased.

Conclusions:

PEI-AgNCs are promising novel antibacterial agents.
Reduced PEI molecular weight correlates with enhanced antibacterial efficacy.
These materials hold potential for practical clinical applications in combating bacterial infections.