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Published on: January 4, 2017
Proteolytic control over formation of enzymic complexes of the mitochondrial inner membrane
1Belozersky Laboratory of Molecular Biology and Bioorganic Chemistry, Moscow State University, USSR.
Abstract:
Assembly of enzymic complexes of the mitochondrial inner membrane is an intricate process involving import of protein precursors from the cytosol and from the mitochondrial matrix, proteolytic processing of the precursors, covalent and noncovalent attachment of prosthetic groups to apoproteins, diffusion of proteins in the membrane in search of their partners, etc. The aim of the present communication is to draw attention to that, concurrent with all these events, proteolysis of mitochondrial inner membrane proteins occurs, which in some cases is rapid and can play a prominent part in correcting polypeptide compartmentation, subunit stoichiometry in complexes, overall amounts of proteins and mutual arrangement of complexes in the membrane.
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