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[THE MODES OF EVALUATION OF TYPE OF DEHYDRATION IN CHILDREN HOSPITALIZED BECAUSE OF ACUTE INTESTINAL INFECTION]

E A Krieger, O V Samodova, N N Gulakova

    Klinicheskaia Laboratornaia Diagnostika
    |March 23, 2016
    PubMed

    Insights

    A simple formula can accurately estimate blood plasma osmolarity in children with dehydration from intestinal infections, guiding appropriate treatment for water-electrolyte imbalances.

    Area of Science:

    • Pediatrics
    • Clinical Chemistry
    • Internal Medicine

    Context:

    • Acute intestinal infections frequently cause dehydration, leading to severe outcomes, including death.
    • Accurate assessment of dehydration type is crucial for effective treatment, but instrumental measurement of blood osmolarity is often unavailable.
    • Existing methods for estimating osmolarity lack precision, necessitating improved diagnostic approaches.

    Purpose:

    • To evaluate the precision of an indirect estimation formula for blood plasma osmolarity compared to instrumental measurement.
    • To identify a reliable method for assessing dehydration in children hospitalized with acute intestinal infections.

    Summary:

    • This study compared instrumental blood plasma osmolarity measurements with five estimation techniques in 32 children experiencing dehydration due to intestinal infections.
    • The formula 2x[Na+kp] + [glucosekp] (mmol/l) demonstrated the highest precision, yielding results comparable to instrumental measurements.
    • The Bland-Altman graphic technique was used to assess the agreement between instrumental and estimated osmolarity values.

    Impact:

    • Provides a practical and precise method for estimating blood plasma osmolarity in pediatric dehydration cases.
    • Facilitates rational therapy for water-electrolyte disorders in resource-limited settings.
    • Aims to reduce lethal outcomes associated with dehydration from intestinal infections.

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