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Related Experiment Video

Updated: Mar 23, 2026

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
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Preeclampsia: Long-term effects on pediatric disability.

C Nicolás1, P Rodríguez Benítez2, M O Arroyo Riaño3

  • 1Hospital General Universitario Gregorio Marañón, Universidad Complutense de Madrid, Madrid, Spain.

Journal of Neonatal-Perinatal Medicine
|March 23, 2016
PubMed
Summary
This summary is machine-generated.

Preeclampsia is linked to lower social/cognitive development in children. This study found lower scores in this area were associated with maternal IgG levels and necrotizing enterocolitis in newborns.

Keywords:
PEDI-CATQuality of lifeTAPQOLautism spectrum disorderscognitive delaygut microbiomeimmunoglobulin Gnecrotizing enterocolitissocial functioning

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Area of Science:

  • Obstetrics and Gynecology
  • Pediatric Neurology
  • Developmental Pediatrics

Background:

  • Preeclampsia affects 10% of pregnancies globally, contributing to fetal morbidity and mortality.
  • While linked to developmental delay, long-term neurologic effects in children require further quantification.

Purpose of the Study:

  • To assess the correlation between preeclampsia severity, obstetric management, and infant disability.
  • To investigate the impact of preeclampsia on children's neurodevelopmental outcomes.

Main Methods:

  • Observational study of 96 mothers with preeclampsia and 111 children.
  • Data collected on maternal history, preeclampsia management, fetal growth, birth distress markers, and diagnoses.
  • Pediatric Evaluation of Disability Inventory (PEDI-CAT) and TNO-AZL Preschool children Quality of Life (TAPQOL) used for assessment.

Main Results:

  • Children exposed to preeclampsia showed lower PEDI-CAT scores in the social/cognitive domain.
  • Lower social/cognitive performance correlated with reduced maternal IgG levels.
  • Necrotizing enterocolitis in neonates was also associated with poorer social/cognitive outcomes.

Conclusions:

  • A significant association exists between preeclampsia and adverse social/cognitive development in children.
  • Further research is warranted to understand and mitigate these long-term effects.