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A Semi-high-throughput Imaging Method and Data Visualization Toolkit to Analyze C. elegans Embryonic Development
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Emerging Imaging and Genomic Tools for Developmental Systems Biology
1Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA.
Developmental Cell
|March 23, 2016
Summary
Understanding animal development requires precisely coordinated cellular processes. New imaging and genomics technologies offer a systems-level view of these dynamic behaviors and molecular mechanisms.
Area of Science:
- Developmental Biology
- Cellular Dynamics
- Genomics
Background:
- Animal development involves complex, timed cellular events like lineage commitment, division, and migration.
- Genetic and stem cell studies have illuminated molecular pathways in cellular differentiation.
- The spatiotemporal coordination of these pathways at the whole-organism level remains poorly understood.
Purpose of the Study:
- To explore how precise coordination of developmental pathways is achieved.
- To understand the establishment of developmental spatiotemporal choreography.
- To propose an integrated approach for deciphering in vivo cellular dynamics.
Main Methods:
- Review of recent technological advances in imaging.
- Integration of single-cell genomics techniques.
- Quantitative analysis of in vivo cellular behaviors.
Main Results:
- Technological advances in imaging and single-cell genomics are crucial.
- An integrated approach can provide systems-level insights.
- Single-cell, single-molecule resolution is achievable for studying development.
Conclusions:
- Advanced imaging and single-cell genomics promise deeper understanding of animal development.
- An integrated approach combining these technologies is proposed.
- This approach enables quantitative deciphering of in vivo cellular dynamics and molecular mechanisms.
