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Updated: Mar 23, 2026

Single-throughput Complementary High-resolution Analytical Techniques for Characterizing Complex Natural Organic Matter Mixtures
Published on: January 7, 2019
Sol-gel approach for extracting highly versatile aspirin and its metabolites using MISPE followed by GC-MS/MS
Tejasvi Bhatia1,2, Manoj Kumar Gupta1,2, Pratibha Singh1
1Analytical Chemistry Laboratory, Regulatory Toxicology Group, CSIR-IITR, MG Marg, Lucknow 226001, India.
Aim:
Aspirin is known to be a salicylate drug widely used as an analgesic, antipyretic and anti-inflammatory drug.
Methodology:
Sol-gel based nanosized molecularly imprinted polymer (nMIP) has been synthesized for extraction of aspirin and its metabolites in urine followed by GC-MS/MS analysis.
Results:
Binding affinity of nMIP and nonimprinted polymer was found to be in the range of 70-95% and 29-45%, respectively. LOD and LOQ of aspirin and its metabolites were found to be in the range of 0.63-2.4 ng/ml and 2.07-7.68 ng/ml, respectively.
Conclusion:
The developed method was found to be applicable for routine analysis of aspirin and its metabolites in biological samples.

