Deceleration and acceleration capacities of heart rate associated with heart failure with high discriminating...

Area of Science:

• Cardiology
• Autonomic Nervous System Research
• Heart Failure Pathophysiology

Background:

• Accurate assessment of autonomic nerve regulation in heart failure (HF) remains a challenge.
• Understanding the role of autonomic dysfunction is crucial for managing HF.

Purpose of the Study:

• To evaluate the diagnostic performance of heart rate acceleration capacity (AC) and deceleration capacity (DC) in identifying heart failure.
• To determine if AC and DC are independent risk factors for HF in males and females.

Main Methods:

• The study included 130 HF patients and 212 controls.
• Multiple logistic regression analysis and receiver operating characteristic (ROC) curve analysis were used.
• AC and DC values were measured and compared between groups.

Main Results:

• Both AC and DC were identified as independent risk factors for HF in males (ORs 5.94 and 0.13) and AC in females (OR 8.58).
• DC demonstrated superior classification performance for HF in males (AUC 0.88) and females (AUC 0.97), outperforming left ventricular ejection fraction (LVEF).
• AC also showed high classification performance in males (AUC 0.84) and females (AUC 0.92).

Conclusions:

• Heart rate AC and DC are valuable, independent predictors of HF.
• DC is a highly effective electrophysiological index for classifying HF in both sexes.
• These measurements provide critical insights into the neuro-pathophysiology of heart failure.