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Cellular immune function and liver damage in post-hepatitic cirrhosis
1Zhi-Jie Feng, Ran-Ming Niu, Xi-Ling Ren, Xi-Xian Yao, Department of Internal Medicine, Second Affiliated Hospital, Hebei Medical University, Shijiazhuang 050000, Hebei Province, China.
World Journal of Gastroenterology
|March 24, 2016
Summary
Cellular immune function is impaired in patients with post-hepatitic cirrhosis (PHC). This immune dysfunction correlates with the severity of liver damage, as indicated by Child-Pugh classification.
Area of Science:
- Immunology
- Hepatology
- Cellular Biology
Background:
- Post-hepatitic cirrhosis (PHC) is a significant cause of liver damage.
- Cellular immune function plays a crucial role in managing liver disease progression.
- Understanding immune status in PHC is vital for assessing disease severity.
Purpose of the Study:
- To investigate cellular immune function in patients with PHC.
- To determine the relationship between immune function and the degree of liver damage in PHC patients.
Main Methods:
- Studied 51 PHC patients (Child-Pugh A, B, C) and 22 healthy controls.
- Isolated peripheral blood mononuclear cells.
- Assessed lymphocyte transformation (LT), IL-2 activity, and NK cell activity using (3)H-TdR incorporation.
Main Results:
- PHC patients showed significantly decreased LT stimulation index, IL-2 activity, and NK cell activity compared to controls.
- Immune function defects were closely related to Child-Pugh classification.
- Immune function was significantly lower in Child-Pugh class C than B and A, and in B than A.
Conclusions:
- Patients with PHC exhibit defective cellular immune functions.
- The degree of immune dysfunction in PHC is directly associated with the severity of liver damage.
Keywords:
HepatitisImmunity, cellularImmunologyInterleukinKiller cells, naturalLiver cirrhosisLymphocyte transformationMore Related Videos
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