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Multiplexed Isothermal Amplification Based Diagnostic Platform to Detect Zika, Chikungunya, and Dengue 1
Published on: March 13, 2018
The Chikungunya virus: An emerging US pathogen
Thomas M Nappe1, Craig M Chuhran2, Steven A Johnson1
1Department of Emergency Medicine, Lehigh Valley Hospital, USF Morsani College of Medicine, PA 18103, USA.
Insights
Chikungunya virus (CHIK) has been detected in the United States. This case documents an early CHIK infection in Pennsylvania following travel to Haiti, highlighting the need for clinical awareness.
Area of Science:
- Virology
- Infectious Diseases
- Public Health
Background:
- The Chikungunya virus (CHIK) has recently been reported by the CDC to have spread to the United States.
- This report details an early documented case of CHIK in Pennsylvania in 2014.
Observation:
- A 39-year-old male traveler returning from Haiti presented with fever, fatigue, polyarthralgias, and a rash.
- Four accompanying friends also reported similar symptoms.
- Diagnostic testing confirmed a positive CHIK antibody titer.
Findings:
- The patient's condition improved within two days with supportive care, including anti-inflammatories, IV hydration, and anti-emetics.
- The patient was discharged home in stable condition.
Implications:
- Chikungunya virus (CHIK) manifestations can mimic Dengue fever, a co-infection transmitted by the same mosquito species.
- Clinicians should consider CHIK in the differential diagnosis for patients with fever, polyarthralgia, and rash, especially with a travel history to endemic areas, including within the U.S.
Background:
The Chikungunya (CHIK) virus was recently reported by the CDC to have spread to the United States. We report an early documented case of CHIK from the state of Pennsylvania after a patient recently returned from Haiti in June of 2014.
Methods:
A 39-year-old man presented to the emergency department complaining of fever, fatigue, polyarthralgias and a diffuse rash for two days. Four days before, he returned from a mission trip to Haiti and reported that four of his accompanying friends had also become ill. A CHIK antibody titer was obtained and it was found to be positive. During his hospital stay, he responded well to supportive care, including anti-inflammatories, intravenous hydration and anti-emetics.
Results:
His condition improved within two days and he was ultimately discharged home.
Conclusions:
Manifestations of CHIK can be similar to Dengue fever, which is transmitted by the same species of mosquito, and occasionally as a co-infection. Clinicians should include Chikungunya virus in their differential diagnosis of patients who present with fever, polyarthralgia and rash with a recent history of travel to endemic areas, including those within the United States.
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