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Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis
Published on: February 10, 2015
Bile Nephropathy in Flucloxacillin-Induced Cholestatic Liver Dysfunction
Basil Alnasrallah1, John F Collins1, L Jonathan Zwi2
1Department of Nephrology, Auckland City Hospital, Auckland 1023, New Zealand.
Abstract:
Kidney injury in the context of cholestatic liver dysfunction is not uncommon; this has been historically referred to as cholemic nephrosis implying a direct deleterious renal effect of cholemia. However, scepticism about the exact role that bile and its constituents play in this injury has led to the disappearance of the term. We describe a case of severe AKI due to bile nephropathy with bile casts in flucloxacillin-induced liver dysfunction. We also discuss the recent literature reviving the concept of bile nephropathy.
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