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Relationship of Estimated GFR and Albuminuria to Concurrent Laboratory Abnormalities: An Individual Participant Data

Lesley A Inker1, Morgan E Grams2, Andrew S Levey1

  • 1Division of Nephrology, Tufts Medical Center, Boston, MA.

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
|October 24, 2018
PubMed

Insights

Lower estimated glomerular filtration rate (eGFR) strongly correlates with multiple laboratory abnormalities in chronic kidney disease (CKD) patients. This finding may aid in managing diverse CKD patient populations.

Area of Science:

  • Nephrology
  • Clinical Chemistry
  • Epidemiology

Background:

  • Chronic kidney disease (CKD) involves kidney function disruptions.
  • Existing staging frameworks for CKD include estimated glomerular filtration rate (eGFR) and albuminuria.
  • The relationship between CKD stage and specific laboratory abnormalities requires further investigation.

Purpose of the Study:

  • To examine the association between CKD staging parameters (eGFR and albuminuria) and various laboratory abnormalities.
  • To determine if these associations differ based on the CKD staging framework used.

Main Methods:

  • Individual participant-level data from 17 CKD cohorts and 38 general population/high-risk cohorts were analyzed.
  • Linear and logistic regression models assessed associations between eGFR/albuminuria and laboratory results/hypertension.
  • Results were pooled using random-effects meta-analyses.

Main Results:

  • A strong, graded association was observed between lower eGFR and multiple laboratory abnormalities.
  • Lower eGFR demonstrated significantly higher odds of abnormalities compared to higher eGFR.
  • Albuminuria showed weaker or equivocal associations with these laboratory abnormalities.

Conclusions:

  • Lower eGFR is a robust predictor of multiple laboratory abnormalities in CKD.
  • Understanding these risk associations can inform clinical management strategies for CKD patients.
  • The findings highlight the importance of eGFR in identifying patients with potential complications.
Abstract

Keywords:
CKD Prognosis ConsortiumCKD stageChronic kidney disease (CKD)albuminuriaanemiadiabetesglomerular filtration rate (GFR)hematocrithemoglobinhyperparathyroidismhypertensionindividual-level meta-analysiskidney functionlaboratory abnormalitylaboratory testsmeta-analysisserum bicarbonateserum calciumserum intact parathyroid hormoneserum phosphorusserum potassiumstaging system

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