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[Hyperuricemia, gout and cardiovascular diseases]

Karsten Murray1,2, Thilo Burkard1,2

  • 11 Abteilung für Kardiologie, Universitätsspital Basel.

Therapeutische Umschau. Revue Therapeutique
|March 24, 2016
PubMed

Insights

High uric acid levels and gout are linked to cardiovascular issues. Clinicians should manage cardiovascular risk factors in these patients, but preventive urate-lowering treatment is only advised in specific cases.

Area of Science:

  • Cardiology
  • Rheumatology
  • Metabolic Diseases

Context:

  • Hyperuricemia and gout frequently coexist with arterial hypertension and metabolic syndrome.
  • These conditions are associated with significant cardiovascular comorbidities and elevated cardiovascular risk.
  • The independent and causal nature of this association requires further investigation.

Purpose:

  • To review the clinical implications of hyperuricemia and gout in patients with cardiovascular comorbidities.
  • To emphasize the importance of managing cardiovascular risk factors in patients with hyperuricemia and gout.
  • To discuss the current evidence and recommendations regarding urate-lowering therapy for cardiovascular risk reduction.

Summary:

  • Hyperuricemia and gout are prevalent conditions often seen with hypertension and metabolic syndrome, carrying a high cardiovascular risk.
  • While pathophysiological links exist, the independent and causal relationship between hyperuricemia/gout and cardiovascular disease needs clarification.
  • Comprehensive identification and treatment of cardiovascular risk factors are crucial for all patients with hyperuricemia and gout.

Impact:

  • Highlights the need for integrated management of metabolic and cardiovascular health.
  • Informs clinical practice regarding risk assessment and treatment strategies for patients with hyperuricemia and gout.
  • Underscores the limited current indications for preventive urate-lowering therapy in asymptomatic hyperuricemia concerning cardiovascular outcomes.

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