[Therapy of cancer of the prostate in stage C]

For stage C tumors that are not large, radical prostatectomy and immediate hormone therapy are advocated. For very large tumors or those not amenable to complete excision because of tumor location, preoperative hormone therapy for 3 to 4 months is advocated to reduce tumor mass. Thereafter surgery can be performed and hormone therapy continued post-operatively. Because few patients are diagnosed with stage C and D1 tumors in Spain, these cases should be referred to a limited number of hospitals in the interest of acquiring more data and experience.