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Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
Published on: September 21, 2017
Small molecule-mediated duplex formation of nucleic acids with 'incompatible' backbones
Brian J Cafferty1, Caterina Musetti1, Keunsoo Kim2
1School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30033, USA. hud@chemistry.gatech.edu.
Abstract:
Proflavine, a known intercalator of DNA and RNA, promotes duplex formation by nucleic acids with natural and non-natural backbones that otherwise form duplexes with low thermal stability, and even some that show no sign of duplex formation in the absence of proflavine. These findings demonstrate the potential for intercalators to be used as cofactors for the assembly of rationally designed nucleic acid structures, and could provide fundamental insights regarding intercalation of natural nucleic acid duplexes.
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