Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[ONCONNECTE À L'EMPLOI, feedback after three years of a program to prepare for returning to work after cancer in Franche-Comté].

Bulletin du cancer·2026
Same author

Diagnostic accuracy of <sup>18</sup>F-FDG PET-CT scores in distinguishing polymyalgia rheumatica from other inflammatory rheumatic diseases: a multicentre retrospective study (RHUMATEP).

European journal of nuclear medicine and molecular imaging·2026
Same author

A Conserved 3'UTR Stem-loop Directs UPF1/eIF4AIII-Dependent Regulation of GABARAPL1 mRNA.

Journal of molecular biology·2026
Same author

GABARAPL1 is important for the activation of HRI during eIF2α phosphorylation-dependent stress response to sodium arsenite.

Scientific reports·2026
Same author

Perioperative treatment in resectable gastric cancer with spartalizumab in combination with fluorouracil, leucovorin, oxaliplatin and docetaxel (FLOT): Results from the GASPAR phase 2 study.

European journal of cancer (Oxford, England : 1990)·2026
Same author

Ezabenlimab with induction chemotherapy and adaptive chemoradiotherapy in stage 3 squamous cell anal carcinoma - Authors' reply.

The Lancet. Oncology·2026

Related Experiment Video

Updated: Mar 23, 2026

In Vivo Proximity Biotinylation for Protein Interaction Studies in Paramecium tetraurelia
06:43

In Vivo Proximity Biotinylation for Protein Interaction Studies in Paramecium tetraurelia

Published on: September 12, 2025

1.4K

Nanovectorization of DNA Through Cells Using Protamine Complexation.

Khaoula Boukari1, Cécile Caoduro1, Raoudha Kacem1

  • 1Nanomedicine, Imagery and Therapeutics Laboratory, EA - 4662, UFR Sciences et Techniques, CHU-UFR SMP, Université de Bourgogne Franche Comté, 19 Rue Ambroise Paré, 25030, Besancon Cedex, France.

The Journal of Membrane Biology
|March 25, 2016
PubMed
Summary

Carbon nanotubes (CNTs) show potential as nanovectors for delivering therapeutic DNA. Molecular dynamics simulations explore their use in forming protamine-DNA-CNT complexes for effective gene delivery.

Keywords:
NanovectorizationProtamineSimulation

More Related Videos

Author Spotlight: Advancements in DNA Nanosensors &#8211; Addressing Sensitivity and Selectivity Challenges in Molecular Detection
07:16

Author Spotlight: Advancements in DNA Nanosensors – Addressing Sensitivity and Selectivity Challenges in Molecular Detection

Published on: February 9, 2024

1.7K
Combining QD-FRET and Microfluidics to Monitor DNA Nanocomplex Self-Assembly in Real-Time
14:36

Combining QD-FRET and Microfluidics to Monitor DNA Nanocomplex Self-Assembly in Real-Time

Published on: August 26, 2009

11.7K

Related Experiment Videos

Last Updated: Mar 23, 2026

In Vivo Proximity Biotinylation for Protein Interaction Studies in Paramecium tetraurelia
06:43

In Vivo Proximity Biotinylation for Protein Interaction Studies in Paramecium tetraurelia

Published on: September 12, 2025

1.4K
Author Spotlight: Advancements in DNA Nanosensors &#8211; Addressing Sensitivity and Selectivity Challenges in Molecular Detection
07:16

Author Spotlight: Advancements in DNA Nanosensors – Addressing Sensitivity and Selectivity Challenges in Molecular Detection

Published on: February 9, 2024

1.7K
Combining QD-FRET and Microfluidics to Monitor DNA Nanocomplex Self-Assembly in Real-Time
14:36

Combining QD-FRET and Microfluidics to Monitor DNA Nanocomplex Self-Assembly in Real-Time

Published on: August 26, 2009

11.7K

Area of Science:

  • Nanotechnology
  • Biomaterials Science
  • Molecular Biology

Background:

  • Carbon nanotubes (CNTs) are recognized for their potential as nanovectors in drug delivery.
  • Their cellular penetration capabilities have led to applications as drug nanocarriers.
  • CNTs can be functionalized to carry various therapeutic molecules to target cells.

Purpose of the Study:

  • To theoretically investigate the potential of carbon nanotubes (CNTs) for transporting and delivering DNA.
  • To explore the formation of a protamine-DNA-CNT complex for enhanced gene delivery.

Main Methods:

  • Utilizing molecular dynamics (MD) simulations.
  • Analyzing the structural and dynamic properties of the protamine-DNA-CNT complex.

Main Results:

  • Demonstrated the feasibility of forming a stable protamine-DNA-CNT complex.
  • Provided theoretical insights into the interaction mechanisms between DNA, protamine, and CNTs.
  • Indicated CNTs' capacity to facilitate DNA transport.

Conclusions:

  • Carbon nanotubes show promise as carriers for DNA delivery via protamine complexation.
  • Molecular dynamics simulations offer a valuable approach to understanding nanocarrier-DNA interactions.
  • Further research could optimize CNT-based systems for gene therapy applications.