Secretory Meningiomas: Characteristic Features and Clinical Management of a Unique Subgroup

Area of Science:

• Neuro-oncology
• Pathology
• Neurosurgery

Background:

• Secretory meningiomas (SM) are a rare subtype of meningioma, the most common benign intracranial tumor.
• SM are histologically defined by eosinophilic glandular structures and periodic-acidic Schiff-positive pseudopsammoma bodies.
• These tumors present unique molecular alterations and a propensity for extensive peritumoral brain edema.

Purpose of the Study:

• To highlight the distinct features of secretory meningiomas.
• To emphasize the clinical significance of peritumoral edema in SM.
• To underscore the need for increased awareness regarding perioperative complications associated with SM.

Main Methods:

• Histopathological analysis for characteristic features (glandular formations, pseudopsammoma bodies).
• Molecular profiling to identify unique alterations.
• Clinical case review focusing on edema extent and perioperative outcomes.

Main Results:

• Secretory meningiomas exhibit specific histological and molecular profiles.
• Extensive peritumoral brain edema is a frequent hallmark of SM.
• The pathophysiology of edema in SM remains largely unknown.

Conclusions:

• Secretory meningiomas require specialized diagnostic and management approaches.
• The significant peritumoral edema associated with SM necessitates heightened vigilance for perioperative risks.
• Further research is crucial to elucidate the mechanisms of edema formation in secretory meningiomas.