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Forensic neuropathology: 2026 update.

Jakob Matschke¹

¹Institute of Neuropathology and Forensic Neuropathology Unit, Institute of Neuropathology & Institute of Forensic Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Free Neuropathology

|May 22, 2026

Summary

This summary is machine-generated.

Forensic neuropathology advances in 2025 highlight abusive head trauma (AHT) mechanisms and chronic traumatic encephalopathy (CTE) in new populations. Research also explores sudden unexpected death in epilepsy (SUDEP) and AI

Keywords:

Abusive head trauma CTE Chronic traumatic encephalopathy Forensic neuropathology IPV Intimate partner violence Neurotraumatology SIDS SUDEP Sudden infant death syndrome Sudden unexpected death in epilepsy TBI Traumatic brain injury

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Area of Science:

Forensic Neuropathology
Neuroscience
Biomedical Research

Background:

The 2025 literature reveals evolving insights into critical areas of forensic neuropathology.
Key topics include abusive head trauma (AHT), chronic traumatic encephalopathy (CTE), and sudden unexpected death in epilepsy (SUDEP).

Purpose of the Study:

To review significant publications in forensic neuropathology from the 2025 literature.
To highlight advancements in understanding injury mechanisms, disease pathology, and diagnostic tools.

Main Methods:

Literature review of key publications from 2025.
Analysis of research on biomechanical models, neuroimaging, clinicopathological correlation, and biomarker studies.

Main Results:

Biomechanical models clarify AHT mechanisms, but subtle pathology detection remains challenging.
CTE understanding expands to intimate partner violence victims; SUDEP research shows overlap with SIDS.
AI shows potential in TBI and epilepsy analysis; new biomarkers and cerebellum vulnerability are explored.

Conclusions:

Forensic neuropathology relies on excluding other causes of death.
Advancements in neuroimaging, biomarkers, and AI promise improved diagnostic capabilities.
Further research is needed to integrate new findings into routine forensic practice.