Calcium sodium phosphosilicate had some benefit on dentine hypersensitivity

Area of Science:

• Dental Science
• Clinical Trials
• Evidence-Based Dentistry

Background:

• Dentine hypersensitivity (DH) is a common dental condition causing pain.
• Topical சிகிச்சைகள், including those with calcium sodium phosphosilicate (CSPS), are used to manage DH.
• The efficacy and safety of CSPS for DH require systematic evaluation.

Purpose of the Study:

• To systematically review randomized controlled trials (RCTs) evaluating topical CSPS for DH.
• To assess the efficacy of CSPS in reducing DH pain compared to placebo.
• To evaluate the incidence of adverse events associated with CSPS use.

Main Methods:

• Searched multiple databases (Medline, Embase, Web of Science, CENTRAL, CBM) for RCTs.
• Included studies compared topical CSPS to a negative (placebo) control in human participants with DH.
• Extracted data on DH pain response and side effects; meta-analysis was performed where appropriate; evidence quality was assessed using GRADE.

Main Results:

• Eleven trials were included; five studies showed low risk of bias, one high, and five unclear.
• Five percent CSPS toothpaste demonstrated a desensitizing effect compared to negative control (moderate evidence).
• Fifteen percent CSPS prophylaxis paste showed a desensitizing effect post-periodontal therapy (low evidence); few adverse events were reported.

Conclusions:

• Topical CSPS, particularly 5% in toothpaste, is effective in alleviating dentine hypersensitivity.
• Prophylaxis paste with 15% CSPS may be beneficial for post-periodontal therapy DH.
• Further research is needed to clarify potential side effects of higher CSPS concentrations.