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Evaluation of the Storage Stability of Extracellular Vesicles
Published on: May 22, 2019
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Extracellular vesicles as new players in angiogenesis
Sharad Kholia1, Andrea Ranghino1, Paolo Garnieri2
1Molecular Biotechnology Center, Department of Medical Sciences, Corso Dogliotti 14, 10126 Torino, Italy.
Vascular Pharmacology
|March 26, 2016
Summary
Cell-released vesicles, including exosomes and microvesicles, carry regulatory molecules. These vesicles mediate intercellular communication and are increasingly recognized as key players in blood vessel formation (angiogenesis).
Area of Science:
- Cell biology
- Molecular biology
- Angiogenesis research
Background:
- Cells release small vesicles containing RNA and regulatory molecules.
- These vesicles facilitate intercellular communication via biological fluids.
- Membrane vesicles like exosomes and microvesicles are emerging as angiogenic mediators.
Purpose of the Study:
- To review the role of cell-derived vesicles in angiogenesis.
- To discuss their mechanisms of action in physiological and pathological contexts.
Main Methods:
- Literature review of studies on vesicles and angiogenesis.
- Analysis of mechanisms involved in vesicle-mediated intercellular signaling.
- Synthesis of current knowledge on vesicle involvement in blood vessel formation.
Main Results:
- Cell-derived vesicles actively transport regulatory molecules between cells.
- Exosomes and microvesicles are implicated in both promoting and inhibiting angiogenesis.
- Vesicle content and function are crucial for regulating angiogenic processes.
Conclusions:
- Cell-derived vesicles are significant mediators of intercellular communication in angiogenesis.
- Understanding vesicle function is critical for therapeutic strategies targeting blood vessel formation.
- Further research is needed to fully elucidate the complex roles of vesicles in angiogenesis.
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