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Updated: Mar 23, 2026

Cell-based Assay Protocol for the Prognostic Prediction of Idiopathic Scoliosis Using Cellular Dielectric Spectroscopy
Published on: October 16, 2013
[Genome-wide association study for adolescent idiopathic scoliosis]
Yoji Ogura1, Ikuyo Kou2,
1Department of Orthopaedic Surgery, Keio University, Japan.Laboratory of Bone and Joint Diseases, RIKEN Center for Integrative Medical Sciences, Japan.
Abstract:
Adolescent idiopathic scoliosis(AIS)is a polygenic disease. Genome-wide association studies(GWASs)have been performed for a lot of polygenic diseases. For AIS, we conducted GWAS and identified the first AIS locus near LBX1. After the discovery, we have extended our study by increasing the numbers of subjects and SNPs. In total, our Japanese GWAS has identified four susceptibility genes. GWASs for AIS have also been performed in the USA and China, which identified one and three susceptibility genes, respectively. Here we review GWASs in Japan and abroad and functional analysis to clarify the pathomechanism of AIS.
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