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Published on: August 9, 2022
Monitoring model drug microencapsulation in PLGA scaffolds using X-ray powder diffraction
Adeyinka Aina1, Manish Gupta2, Yamina Boukari3
1Department of Mathematics and Natural Science, American University of Iraq, Kirkuk Main Road, Raparin, Sulaimani, Iraq; Drug Delivery Laboratory, School of Pharmacy, University of Nottingham Malaysia Campus, Jalan Broga, 43500 Semenyih, Selangor Darul Ehsan, Malaysia.
Abstract:
The microencapsulation of three model drugs; metronidazole, paracetamol and sulphapyridine into Poly (dl-Lactide-Co-Glycolide) (PLGA) scaffolds were probed using X-ray Powder Diffraction (XRPD). Changes in the diffraction patterns of the PLGA scaffolds after encapsulation was suggestive of a chemical interaction between the pure drugs and the scaffolds and not a physical intermixture.

