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Hollow Fiber Bioreactors for In Vivo-like Mammalian Tissue Culture
Published on: May 26, 2016
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Biomaterials for hollow organ tissue engineering
Eseelle K Hendow1, Pauline Guhmann1, Bernice Wright1
1Applied Biomedical Engineering Group, Division of Medicine, University College London, 21 University Street, London, UK.
Fibrogenesis & Tissue Repair
|March 26, 2016
Summary
Tissue engineering offers promising solutions for hollow organ replacement and repair. This review explores biomaterial scaffolds and fabrication methods for creating functional, tissue-engineered organs.
Area of Science:
- Regenerative Medicine
- Biomaterials Science
- Organ Engineering
Background:
- Tissue engineering is advancing rapidly, with significant potential to revolutionize medical treatments.
- Hollow organs in the cardiovascular, respiratory, and gastrointestinal systems are key targets for tissue engineering applications.
- Engineered constructs often necessitate biomaterial scaffolds for structural support and tissue regeneration.
Purpose of the Study:
- To review current approaches in fabricating scaffolds for hollow organ tissue engineering.
- To discuss the selection criteria for biomaterials used in these scaffolds.
- To highlight considerations for matching engineered tissue properties to native tissue characteristics.
Main Methods:
- Review of existing literature on hollow organ scaffold fabrication techniques.
- Analysis of biomaterial properties relevant to tissue engineering applications.
- Discussion of manufacturing processes for creating tissue-engineered constructs.
Main Results:
- Various fabrication methods exist for hollow organ scaffolds.
- Biomaterial choice and manufacturing processes are critical for achieving desired mechanical and physiological properties.
- Matching native tissue characteristics is essential for successful de novo tissue formation.
Conclusions:
- Tissue engineering holds transformative potential for hollow organ repair and replacement.
- Careful selection of biomaterials and fabrication methods is crucial for successful organ regeneration.
- Further research into biomaterial-scaffold interactions will advance the field.
