Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

iPS Cell Differentiation

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Effects of gallium and clove oil embedded in porous phosphate coacervate glass fibres on wound healing.

Materials advances·2026

Same author

In Vivo Microplastic Detection With Photoacoustic Imaging.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026

Same author

Physiological Significance of Endothelial M3 Muscarinic Receptors During Exercise.

Circulation research·2025

Same author

Visualizing Vascular Bone Marrow Niche Alterations in Diabetes.

Arteriosclerosis, thrombosis, and vascular biology·2025

Same author

Correction: Human myofibroblasts increase the arrhythmogenic potential of human induced pluripotent stem cell-derived cardiomyocytes.

Cellular and molecular life sciences : CMLS·2024

Same author

Hierarchically Structured Biodegradable Microspheres Promote Therapeutic Angiogenesis.

Advanced healthcare materials·2024

Search research articles

Related Experiment Video

Updated: Jun 23, 2025

Recombinant Collagen I Peptide Microcarriers for Cell Expansion and Their Potential Use As Cell Delivery System in a Bioreactor Model

Recombinant Collagen I Peptide Microcarriers for Cell Expansion and Their Potential Use As Cell Delivery System in a Bioreactor Model

Published on: February 7, 2018

Injectable biodegradable microcarriers for iPSC expansion and cardiomyocyte differentiation.

Annalisa Bettini^1,2, Patrizia Camelliti³, Daniel J Stuckey¹

¹Centre for Advanced Biomedical Imaging, Division of Medicine, University College London, London, WC1E 6DD, UK.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)

|June 20, 2024

Summary

Injectable microcarriers improve cardiac regeneration by enhancing the survival and delivery of induced pluripotent stem cell-derived cardiomyocytes. This novel approach supports cell growth and retention for potential myocardial infarction therapies.

Keywords:

cardiac regeneration cardiomyocyte maturation injectable biomaterials microcarriers stem cells

More Related Videos

Fabrication of 3D Cardiac Microtissue Arrays using Human iPSC-Derived Cardiomyocytes, Cardiac Fibroblasts, and Endothelial Cells

Fabrication of 3D Cardiac Microtissue Arrays using Human iPSC-Derived Cardiomyocytes, Cardiac Fibroblasts, and Endothelial Cells

Published on: March 14, 2021

Pluripotent Stem Cell Derived Cardiac Cells for Myocardial Repair

Pluripotent Stem Cell Derived Cardiac Cells for Myocardial Repair

Published on: February 3, 2017

Related Experiment Videos

Last Updated: Jun 23, 2025

Recombinant Collagen I Peptide Microcarriers for Cell Expansion and Their Potential Use As Cell Delivery System in a Bioreactor Model

Recombinant Collagen I Peptide Microcarriers for Cell Expansion and Their Potential Use As Cell Delivery System in a Bioreactor Model

Published on: February 7, 2018

Fabrication of 3D Cardiac Microtissue Arrays using Human iPSC-Derived Cardiomyocytes, Cardiac Fibroblasts, and Endothelial Cells

Fabrication of 3D Cardiac Microtissue Arrays using Human iPSC-Derived Cardiomyocytes, Cardiac Fibroblasts, and Endothelial Cells

Published on: March 14, 2021

Pluripotent Stem Cell Derived Cardiac Cells for Myocardial Repair

Pluripotent Stem Cell Derived Cardiac Cells for Myocardial Repair

Published on: February 3, 2017

Area of Science:

Biomaterials Science
Stem Cell Biology
Cardiovascular Research

Background:

Cell therapy shows promise for cardiac regeneration after myocardial infarction.
Current limitations include poor cell retention and survival post-transplantation.
Improved delivery and engraftment strategies are crucial for effective cardiac repair.

Purpose of the Study:

To develop and characterize injectable microcarriers for enhanced delivery of induced pluripotent stem cells (iPSCs).
To evaluate the microcarriers as a substrate for iPSC-derived cardiomyocyte culture and cardiac regeneration.
To assess the potential of microcarrier-based cell therapy for myocardial infarction.

Main Methods:

Fabrication and surface modification of Thermally Induced Phase Separation (TIPS) microcarriers.
Assessment of iPSC attachment, expansion, and phenotype maintenance in xeno-free conditions.
Comparison of iPSC-derived cardiomyocyte differentiation and maturation on microcarriers versus 2D culture.

Main Results:

TIPS microcarriers facilitated iPSC attachment, expansion, and retention of pluripotency.
Microcarrier culture supported mature cardiomyocyte phenotype development.
Microcarriers demonstrated compatibility with injectable delivery and reduced anoikis, improving cell survival.

Conclusions:

TIPS microcarriers serve as a viable supporting matrix for in vitro iPSC and cardiomyocyte culture.
These microcarriers are suitable as an injectable cell-substrate for advancing cardiac regeneration therapies.
This approach offers a promising strategy to overcome cell delivery challenges in myocardial regeneration.