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Updated: Mar 23, 2026
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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
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Current status in outpatient parenteral antimicrobial therapy: a practical view
Francisco Javier Candel1, Agustin Julián-Jiménez, Juan González-Del Castillo
1Francisco Javier Candel González, Department of Clinical Microbiology, Hospital Clínico San Carlos, Avda Dr. Martín Lagos w/n, 28040. Madrid, Spain. fj.candel@gmail.com.
Summary
Outpatient parenteral antimicrobial therapy (OPAT) offers cost-effective infection treatment with improved patient comfort and reduced hospital complications. Careful antibiotic selection and patient management are key to successful OPAT outcomes.
Area of Science:
- Infectious Diseases
- Pharmacology
- Health Services Research
Background:
- Outpatient parenteral antimicrobial therapy (OPAT) is increasingly utilized for its cost-effectiveness, patient comfort, and reduced nosocomial risks.
- OPAT manages diverse infections, including those caused by multidrug-resistant organisms, improving healthcare system economics.
Purpose of the Study:
- To review the critical factors for successful Outpatient Parenteral Antimicrobial Therapy (OPAT).
- To highlight optimal antimicrobial agents and patient selection criteria for OPAT.
Main Methods:
- Literature review of current clinical practices and guidelines for OPAT.
- Analysis of antimicrobial properties and administration methods suitable for outpatient settings.
Main Results:
- Optimal OPAT antimicrobials require high efficacy, long half-lives, and broad-spectrum activity; ceftriaxone and teicoplanin are common, with daptomycin and ertapenem gaining use.
- Self-administration is preferred for patient convenience, necessitating proper training.
- Factors predicting OPAT failure include advanced age, recent hospitalization, and multidrug-resistant organism isolation.
Conclusions:
- Successful OPAT hinges on appropriate antimicrobial choice, patient selection, and administration strategies.
- Careful management can mitigate risks and optimize outcomes for patients receiving parenteral antimicrobials at home.
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